JAESCHKE, GEORG,LINDEMANN, LOTHAR,RICCI, ANTONIO,VIEIRA, ERIC
申请号：
CA2985301
公开号：
CA2985301A1
申请日:
2016.05.31
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to ethynyl derivatives of formula (I) wherein R1 is hydrogen or F； n is 1 or 2 or to a pharmaceutically acceptable acid addition salt thereof. It has now surprisingly been found that the compounds of general formula I are metabotropic glutamate receptor antagonists (negative allosteric modulators) for use in the treatment of anxiety and pain, depression, Fragile-X syndrom, autism spectrum disorders, Parkinson's disease, and gastroesophageal reflux disease (GERD).
