Georg Jaeschke,Lothar Lindemann,Antonio Ricci,Eric Vieira
申请号：
US15829481
公开号：
US20180086680A1
申请日:
2017.12.01
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to ethynyl derivatives of formula Iwith variables as defined herein, or to a pharmaceutically acceptable acid addition salt thereof.Compounds of formula I are metabotropic glutamate receptor antagonists (negative allosteric modulators) for use in the treatment of, e.g., anxiety and pain, depression, Fragile-X syndrome, autism spectrum disorders, Parkinson's disease, and gastroesophageal reflux disease (GERD).
