DISKIN, RON,BJORKMAN, PAMELA, J.,NUSSENZWEIG, MICHEL,SCHEID, JOHANNES
申请号：
EP12818187
公开号：
EP2736532A4
申请日:
2012.07.25
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) potent VRC01-like (PVL) antibodies targeted to gp120 having an amino acid substitution at a residue in the anti-CD4 binding site PVL antibody that is equivalent to Phe43 in CD4, these antibodies having improved potency and breadth.
