COMPOSITIONS AND METHODS FOR IMPROVING POTENCY AND BREADTH OR HIV ANTIBODIES

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专利权人:

发明人:

申请号：

EP12818187.2

公开号：

EP2736532B1

申请日:

2012.07.25

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) potent VRC01-like (PVL) antibodies targeted to gp120 having an amino acid substitution at a residue in the anti-CD4 binding site PVL antibody that is equivalent to Phe43 in CD4, these antibodies having improved potency and breadth.

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中国工程科技知识中心

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http://www.ckcest.cn/home/