PATRICIUS HENDRIKUS CORNELIS VAN BERKEL,PHILIP WILSON HOWARD
申请号：
US15566630
公开号：
US20180099055A1
申请日:
2016.04.15
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Site-specific antibody-drug conjugates are described, in particular conjugates comprising an antibody, which binds CD25 and comprises an amino acid substitution of an interchain cysteine residue by an amino acid that is not cysteine, and pyrrolobenzodiazepines (PBDs) having a labile protecting group in the form of a linker. The site of conjugation, along with modification of the antibody moiety, allows for improved safety and efficacy of the ADC.
