SITE-SPECIFIC ANTIBODY-DRUG CONJUGATES

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专利权人:

发明人:

申请号：

EP16716584.4

公开号：

EP3283119A1

申请日:

2016.04.15

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

Site-specific anti-body-drug conjugates are described, in particular conjugates comprising an antibody, which binds HER2 and comprises an amino acid substitution of an interchain cysteine residue by an amino acid that is not cysteine, and pyrrolobenzodiazepines (PBDs) having a labile protecting group in the form of a linker. The site of conjugation, along with modification of the antibody moiety, allows for improved safety and efficacy of the ADC.

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