The present invention, having on its surface an oligosaccharide capable of binding to the carbohydrate recognition molecules of the surface of antigen-presenting cells, and variants or derivatives its immunologically active or Apical membrane antigen 1 or Dense granule protein 7 of Neospora protozoan and characterized by comprising in encapsulated in liposomes, relates to a vaccine formulation.本発明は、ネオスポラ原虫由来のDense granule protein 7又はApical membrane antigen 1あるいはその免疫学的に活性な変異体又は誘導体を、抗原提示細胞表面の糖鎖認識分子に結合しうるオリゴ糖を表面に有するリポソームに封入してなることを特徴とする、ワクチン製剤に関する。