Domains that bind to non immunized Serum and its use to extend the half-life in Serum

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专利权人:

INC.;MACROGENICS

发明人:

HUANG LING,JOHNSON LESLIE,BONVINI EZIO,BARAT BASHWATI

申请号：

CO13297905

公开号：

CO6970559A2

申请日:

2013.12.20

申请国别(地区):

CO

年份:

2014

代理人:

摘要：

The present invention is directed to a polypeptide (for example, an antigen-binding molecule) that comprises a polypeptide portion of a deimmunized serum-binding protein capable of binding to said serum protein. The presence of the serum-binding protein extends the serum half-life of the polypeptide, relative to the serum half-life of the polypeptide if lacking the polypeptide portion of the deimmunized serum-binding protein. The invention also pertains to methods and uses that employ such molecules.

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