Ezio Bonvini,Bhaswati Barat,Ling Huang,Leslie S. Johnson
申请号：
US16457163
公开号：
US20200095333A1
申请日:
2019.06.28
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention is directed to a polypeptide (for example, an antigen-binding molecule) that comprises a polypeptide portion of a deimmunized serum-binding protein capable of binding to said serum protein. The presence of the serum-binding protein extends the serum half-life of the polypeptide, relative to the serum half-life of the polypeptide if lacking the polypeptide portion of the deimmunized serum-binding protein. The invention also pertains to methods and uses that employ such molecules.
