EZIO BONVINI;LING HUANG;LESLIE S.JOHNSON;MACROGENICS INC.;BHASWATI BARAT
发明人:
申请号：
IL22957613
公开号：
IL229576D0
申请日:
2013.11.21
申请国别(地区):
IL
年份:
2014
代理人:
摘要：
The present invention is directed to a polypeptide (for example, an antigen-binding molecule) that comprises a polypeptide portion of a deimmunized serum-binding protein capable of binding to said serum protein. The presence of the serum-binding protein extends the serum half-life of the polypeptide, relative to the serum half-life of the polypeptide if lacking the polypeptide portion of the deimmunized serum-binding protein. The invention also pertains to methods and uses that employ such molecules.
