Juma′ a Raheem Najeem Al-Dulayy-mi;Johan Adriaan Marc Grooten;Seppe Vander-Beken;Gani Koza;Mark Stephen Baird;Cornelias Theunissen
发明人:
Mark Stephen Baird,Juma′ a Raheem Najeem Al-Dulayy-mi,Cornelias Theunissen,Gani Koza,Seppe Vander-Beken,Johan Adriaan Marc Grooten
申请号：
US12988235
公开号：
US08889894B2
申请日:
2009.04.22
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A compound of formula (I) for use in the treatment of a disease of the immune system； wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms； R1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms； each of R2, R3 and R4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms； each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkenylene, arylene, alkylarylene, cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester and thioketone； and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species； wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C—OR5； wherein R5 is alkyl or haloalkyl, and A is O, S or NR6, wherein R6 may be H or 20 alkyl.
