Formulaciones de inhibidores de DPP IV

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专利权人:

BOEHRINGER INGELHEIM INTERNATIONAL GMBH

发明人:

KOHLRAUSCH, ANJA,ROMER, PATRICK,SEIFFERT, GERD

申请号：

ES10175188

公开号：

ES2538818T3

申请日:

2007.04.30

申请国别(地区):

ES

年份:

2015

代理人:

摘要：

A pharmaceutical composition comprising as active ingredient a DPP IV inhibitor compound with an amino group selected from - 1 - [(4-methyl-quinazolin-2-yl) methyl] -3-methyl-7- (2-butyn-1 -yl) -8- (3- (R) -amino-piperidin-1-yl) -xanthine, - 1 - [([1,5] naphthyridin-2-yl) methyl] -3-methyl-7- ( 2-butyn-1-yl) -8 - ((R) -3-amino-piperidin-1-yl) -xanthine, - 1 - [(quinazolin-2-yl) methyl] -3-methyl-7- ( 2-butyn-1-yl) -8 - ((R) -3-amino-piperidin-1-yl) -xanthine, - 2 - ((R) -3-amino-piperidin-1-yl) -3- (but-2-ynyl) -5- (4-methyl-quinazolin-2-ylmethyl) -3,5-dihydro-imidazo [4,5-d] pyridazin-4-one, - 1 - [(4-methyl quinazolin-2-yl) methyl] -3-methyl-7- (2-butyn-1-yl) -8 - [(2-amino-2-methyl-propyl) -methylamino] -xanthine, - 1- [ (3-cyano-quinolin-2-yl) methyl] -3-methyl-7- (2-butyn-1-yl) -8 - ((R) -3-amino-piperidin-1-yl) -xanthine, - 1- (2-cyano-benzyl) -3-methyl-7- (2-butyn-1-yl) -8 - ((R) -3-amino-piperidin-1-yl) -xanthine, - 1- [(4-methyl-quinazolin-2-yl) methyl] -3-methyl-7- (2-butyn-1-yl) -8 - [(S) - (2-aminopropyl) -methylamino] -xanthine, - 1 - [(3-cyano-pyridin-2-yl) methyl] -3-methy l-7- (2-butyn-1-yl) -8 - ((R) -3-amino-piperidin-1-yl) -xanthine, - 1 - [(4-methyl-pyrimidin-2-yl) methyl ] -3-methyl-7- (2-butyn-1-yl) -8 - ((R) -3-amino-piperidin-1-yl) -xanthine, - 1 - [(4,6-dimethyl-pyrimidine -2-yl) methyl] -3-methyl-7- (2-butyn-1-yl) -8 - ((R) -3-amino-piperidin-1-yl) -xanthine, - 1 - [(quinoxalin -6-yl) methyl] -3-methyl-7- (2-butyn-1-yl) -8 - ((R) -3-amino-piperidin-1-yl) xanthine or a salt thereof, one first diluent, a second diluent, a binder, a disintegrant and a lubricant wherein the first diluent is mannitol and the second diluent is pregelatinized starch.Una composición farmacéutica que comprende como ingrediente activo un compuesto inhibidor de DPP IV con un grupo amino seleccionado de - 1-[(4-metil-quinazolin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-(3-(R)-amino-piperidin-1-il)-xantina, - 1-[([1,5]naftiridin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-((R)-

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