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ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ С ИНГИБИТОРАМИ DPP IV
专利权人:
发明人:
Anja,Аня,Patrick,Патрик,Gerd,Герд
申请号:
EA200802184
公开号:
EA016559B1
申请日:
2007.04.30
申请国别(地区):
EA
年份:
2012
代理人:
摘要:
The present invention relates to pharmaceutical compositions of DPP IV inhibitors with an amino group, selected from 1-[(4-methylquinazolin-2-yl)methyl], 3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine, 1-[([1,5]naphthyridin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-((R)-3-amino-piperidin-1-yl)-xanthine, 1-[(Quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-((R)-3-amino-piperidin-1-yl)-xanthine, 2-((R)-3-Amino-piperidin-1-yl)-3-(but-2-yinyl)-5-(4-methyl-quinazolin-2-ylmethyl)-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one, 1-[(4-Methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyin-1-yl)-8-[(2-amino-2-methyl-propyl)-methylamino]-xanthine, 1-[(3-Cyano-quinolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-((R)-3-amino-piperidin-1-yl)-xanthine, 1-(2-Cyano-benzyl)-3-methyl-7-(2-butyn-1-yl)-8-((R)-3-amino-piperidin-1-yl)-xanthine, 1-[(4-Methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[(S)-(2-amino-propyl)-methylamino]-xanthine, 1-[(3-Cyano-pyridin-2-yl )methyl]-3-methyl-7-(2-butyn-1-yl)-8-((R)-3-amino-piperidin-1-yl)-xanthine (compare WO 2005/085246, example, 1-[(4-Methyl-pyrimidin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-((R)-3-amino-piperidin-1-yl)-xanthine, 1-[(4,6-Dimethyl-pyrimidin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-((R)-3-amino-piperidin-1-yl)-xanthine, 1-[(Quinoxalin-6-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-((R)-3-amino-piperidin-1-yl)-xanthine, or a salt thereof, a first diluent is amannitol, a second diluent is pregelatinized starch, a binder is copovidone, a disintegris corn starch ant and a lubricant is magnesium stearate. The invention also relates to a process for the preparation of a pharmaceutical composition in a dosage medical form prepared by using the above-said pharmaceutical composition.Изобретение относится к фармацевтической композиции, содержащей в качестве действующего вещества ингибитор DPP IV с аминогруппой, такой как соединение, выбранное из 1-[(4-метилхиназолин-2-ил)метил]-3-метил-7-(2-бутин-1-ил)-8-(3-(R)-аминопипери
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