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COMBINED THERAPY FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS
- 专利权人:
- БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГМБХ (DE)
- 发明人:
- МАРК Михаэль (DE),АЙККЕЛЬМАНН Петер (DE),ЛУИППОЛЬД Герд (DE),ТОМАС Лео (DE)
- 申请号：
- RU2011113823/15
- 公开号：
- RU2011113823A
- 申请日:
- 2009.09.08
- 申请国别(地区):
- RU
- 年份:
- 2012
- 代理人:
- 摘要：
- 1. A pharmaceutical composition comprising! GPR119 agonist in combination with! DPP-4 inhibitor of formula (I)! ! or formulas (II)! ! or formula (III)! ! or formula (IV)! ! where R1 is ([1,5] naphthyridin-2-yl) methyl, (quinazolin-2-yl) methyl, (quinoxalin-6-yl) methyl, (4-methylquinazolin-2-yl) methyl, 2-cyanobenzyl, (3-cyanoquinolin-2-yl) methyl, (3-cyanopyridin-2-yl) methyl, (4-methylpyrimidin-2-yl) methyl, or (4,6-dimethylpyrimidin-2-yl) methyl and R2 is 3 - (R) - aminopiperidin-1-yl, (2-amino-2-methylpropyl) methylamino or (2- (S) -aminopropyl) methylamino, or a pharmaceutically acceptable salt thereof. ! 2. The pharmaceutical composition according to claim 1, where the specified DPP-4 inhibitor is selected from the group including:! 1 - [(4-methylquinazolin-2-yl) methyl] -3-methyl-7- (2-butyn-1-yl) -8- (3- (R) -aminopiperidin-1-yl) xanthine,! 1 - [([1,5] naphthyridin-2-yl) methyl] -3-methyl-7- (2-butyn-1-yl) -8 - ((R) -3-aminopiperidin-1-yl) xanthine ! 1 - [(quinazolin-2-yl) methyl] -3-methyl-7- (2-butyn-1-yl) -8 - ((R) -3-aminopiperidin-1-yl) xanthine,! 2 - ((R) -3-aminopiperidin-1-yl) -3- (but-2-ynyl) -5- (4-methylquinazolin-2-ylmethyl) -3,5-dihydroimidazo [4,5-d] pyridazin-4-one,! 1 - [(4-methylquinazolin-2-yl) methyl] -3-methyl-7- (2-butyn-1-yl) -8 - [(2-amino-2-methylpropyl) methylamino] xanthine,! 1 - [(3-cyanoquinolin-2-yl) methyl] -3-methyl-7- (2-butyn-1-yl) -8 - ((R) -3-aminopiperidin-1-yl) xanthine,! 1- (2-cyanobenzyl) -3-methyl-7- (2-butyn-1-yl) -8 - ((R) -3-aminopiperidin-1-yl) xanthine,! 1 - [(4-methylquinazolin-2-yl) methyl] -3-methyl-7- (2-butyn-1-yl) -8 - [(S) - (2-aminopropyl) methylamino] xanthine,! 1 - [(3-cyanopyridin-2-yl) methyl] -3-methyl-7- (2-butyn-1-yl) -8 - ((R) -3-aminopiperidin-1-yl) xanthine,! 1 - [(4-methylpyrimidin-2-yl) methyl] -3-methyl-7- (2-butyn-1-yl) -8 - ((R) -3-aminopiperidin-1-yl) xanthine,! 1 - [(4,6-dimethylpyrimidin-2-yl) methyl] -3-methyl-7- (2-butyn-1-yl) -8 - ((R) -3-aminopiperidin-1-yl) xanthine and ! 1 - [(quino
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