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DPP IV inhibitor formulations
专利权人:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
发明人:
KOHLRAUSCH, ANJA,ROMER, PATRICK,SEIFFERT, GERD
申请号:
NZ59598307
公开号:
NZ595983A
申请日:
2007.04.30
申请国别(地区):
NZ
年份:
2013
代理人:
摘要:
Abstract - 595983 Disclosed is a solid pharmaceutical composition comprising as an active ingredient a DPP IV inhibitor compound as represented by the general formula (I) or (II) with a free or primary amino group or a salt thereof, a first diluent, a second diluent, a binder, a disintegrant and a lubricant: wherein the DPP IV inhibitor is selected from 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-( R)-aminopiperidin-1-yl)-xanthine, 1-[([1,5]naphthyridin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-((R)-3-amino-piperidin-1-yl)-xanthine, 1-[(quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-((R)-3-amino-piperidin-1-yl)-xanthine, 2-((R)-3-amino-piperidin-1-yl)-3-(but-2-yinyl)-5-( 4-methyl-quinazolin-2-ylmethyl)-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one, 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[(2-amino-2-methyl-propyl)-methylamino]-xanthine, 1-[(3-cyano-quinolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-((R)-3-aminopiperidin-1-yl)-xanthine, 1-(2-cyano-benzyl)-3-methyl-7-(2-butyn-1-yl)-8-((R)-3-amino-piperidin-1-yl)-xanthine, 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[(S)-(2-aminopropyl)-methylamino]-xanthine, 1-[(3-cyano-pyridin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-((R)-3-aminopiperidin-1-yl)-xanthine, 1-[(4-methyl-pyrimidin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-((R)-3-aminopiperidin-1-yl)-xanthine, 1-[(4,6-dimethyl-pyrimidin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-((R)-3-amino-piperidin-1-yl)-xanthine, and 1-[(quinoxalin-6-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-((R)-3-amino-piperidin-1-yl)-xanthine, or a salt thereof, and the diluents are selected from erythritol, low substituted hydroxypropyl cellulose, mannitol, pregelatinized starch or xylitol, wherein, the binder is selected from copovidone (copolymerisates of vinylpyrrolidon with other vinylderivates), hydroxypropyl methylcellulose (HPMC), hydroxypropylcellulose (HPC), polyvinylpyrrolidon (povidone), pregelatinized starch, or low-substit
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