FORMAS CRISTALINAS DE 4-[(2,4-DICLORO-5- METOXIFENIL)AMINO]-6-METOXI-7-[3-(4-METIL-1- PIPERAZINIL)PROPOXI]-3-QUINOLINOCARBONITRILO E MÉTODOS DE PREPARAÇÃO DAS MESMAS
MARC SADLER TESCONI,GREGG FEIGELSON,HENRY STRONG,HONG WEN
申请号：
PT06774184
公开号：
PT1902029E
申请日:
2006.06.28
申请国别(地区):
PT
年份:
2014
代理人:
摘要：
This invention is directed to a crystalline 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile monohydrate having an x-ray diffraction pattern wherein 2&thetas； angles (°) of significant peaks are at about: 9.19, 11.48, 14.32, 19.16, 19.45, 20.46, 21.29, 22.33, 23.96, 24.95, 25.29, 25.84, 26.55, 27.61, and 29.51, and a transition temperature of about 109° C. to about 115° C.
