Crystalline forms of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile and methods of preparing the same
Marc Sadler Tesconi;Henry Strong;Hong Wen;Gregg Feigelson
发明人:
Marc Sadler Tesconi,Gregg Feigelson,Henry Strong,Hong Wen
申请号：
US12820306
公开号：
US08445496B2
申请日:
2010.06.22
申请国别(地区):
US
年份:
2013
代理人:
摘要：
This invention is directed to a crystalline 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile monohydrate having an x-ray diffraction pattern wherein 2θ angles (°) of significant peaks are at about: 9.19, 11.48, 14.32, 19.16, 19.45, 20.46, 21.29, 22.33, 23.96, 24.95, 25.29, 25.84, 26.55, 27.61, and 29.51, and a transition temperature of about 109° C. to about 115° C.
