Tom Yao Hsiang Wu,Yongkai Li,Alex Cortez,Yefen Zou,Pranab Mishra,Xiaoyue Zhang,David Skibinski,Manmohan Singh,Nicholas Valiante
申请号：
US12921129
公开号：
US08466167B2
申请日:
2009.02.27
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N； X4 is N Or CR3； X5 is —CR4═CR5.
