Alex Cortez,David Skibinski,Manmohan Singh,Nicholas Valiante,Pranab Mishra,Tom Yao-Hsiang Wu,Xiaoyue Zhang,Yefen Zou,Yongkai Li
申请号：
BRPI0909037
公开号：
BRPI0909037A2
申请日:
2009.02.27
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N； X4 is N Or CR3； X5 is -CR4=CR5.
