The invention relates to a two-layer tablet containing two different active ingredients, namely rosuvastatin of formula I, with the systematic name (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2- yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid or its pharmaceutically acceptable salts, esters, hydrates or solvates, and ezetimibe of formula II, with the systematic name (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3- hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one or its pharmaceutically acceptable salts, esters, hydrates or solvates, and suitable pharmaceutically acceptable excipients, in the shape of circular two-layer tablet. The composition has excellent properties both in terms of its physical characteristics and as regards the release rate of the active substances or product stability.本發明關於一種雙層錠劑,其包含系統分類名為(3R,5S,6E)-7-[4-(4-氟苯基)-2-(N-甲基甲磺醯胺基)-6-(丙烷-2-基)嘧啶-5-基]-3,5-二羥基庚-6-烯酸的式I的瑞舒伐他汀或其藥學上可接受之鹽類、酯類、水合物或溶劑合物,及系統分類名為(3R,4S)-1-(4-氟苯基)-3-[(3S)-3-(4-氟苯基)-3-羥丙基]-4-(4-羥苯基)氮雜環丁烷-2-酮的式II的依澤替米貝或其藥學上可接受之鹽類、酯類、水合物或溶劑合物的兩種不同活性成分,及合適的藥學上可接受的賦形劑在形狀為圓形的雙層錠劑。此組成物在其物理特性和活性物質的釋出率或產物穩定性方面都具有優異的性能。D‧‧‧直徑h‧‧‧高度
