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C2-fluoro substituted piperazine linked pyrrolo[2,1-C][1,4] benzodiazepine dimers and a process for the preparation thereof
专利权人:
Ahmed Kamal
发明人:
Ahmed Kamal,Rajender,Metuku Kashireddy,Gorre Balakishan
申请号:
US12921841
公开号:
US08383618B2
申请日:
2008.10.31
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention provides a compounds of general formula IXa-d, useful as potential antitumour agents and pharmaceutical composition comprising these compounds exhibits binding affinity with calf thymus (CT) DNA at a molar ratio of 1:5 in aqueous sodium phosphate buffer at pH of 7.00. The present invention further provides a process for the preparation of C2-Fluoro substituted piperazine linked pyrrolo[2,1c][1-4], benzodiazepine of formula (IX).
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中国工程科技知识中心
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