HYND, George,TISSELLI, Patrizia,CLARK, David Edward,KULAGOWSKI, Janusz Jozef,MACLEOD, Calum,MANN, Samuel Edward,ROUSSEL, Fabien Jean Ghislain,PRICE, Stephen Colin,MONTANA, John Gary
申请号：
ES14776635
公开号：
ES2643070T3
申请日:
2014.09.25
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula (I): ** (See formula) ** or a tautomer or stereoisomeric form thereof, wherein R1 is selected from the group consisting of hydrogen C1-4 alkyl and C1-4alkyl substituted with one or more fluoro substituents R2 is selected from the group consisting of hydrogen C1-4 alkyl C1-4 alkyl substituted with one or more fluoro substituents C3-6cycloalkyl and Het1 Het1 is selected from the group consisting of thienyl, thiazolyl, pyrrolyl, oxazolyl, pyrazolyl, imidazolyl, isoxazolyl and isothiazolyl heteroaryl, each of which may be optionally substituted with one or two substituents independently selected from halogen and C1-4 alkyl or R1 and R2 together with the carbon atom to which they are attached form a C3-6cycloalkyl R3 is selected from the group consisting of hydrogen halogen cyano C3-6cycloalkyl C1-6 alkyl C1-6 alkyl substituted with one or more fluoro substituents -O (C1-6 alkyl) -O (C1-6 alkyl) substituted with one or more fluoro substituents and C1-6 alkyl substituted with a substituent selected from -NR3aR3b, -OH and -O (C1-4alkyl) R3a and R3b each independently selected from hydrogen and C1-4alkyl R4 is selected from the group consisting of hydrogen halogen C1-4 alkyl and C1-4alkyl substituted with one or more fluoro substituents R5 is selected from the group consisting of hydrogen cyano C1-4 alkyl and C1-4alkyl substituted with one or more fluoro substituents R6 is selected from the group consisting of hydrogen halogen C1-4 alkyl and C1-4alkyl substituted with one or more fluoro substituents R7 is selected from the group ...Un compuesto de Fórmula (I): **(Ver fórmula)** o un tautómero o forma estereoisomérica de este, donde R1 se selecciona a partir del grupo constituido por hidrógeno alquilo C1-4 y alquilo C1-4 sustituido con uno o más sustituyentes fluoro R2 se selecciona a partir del grupo constituido por hidrógeno alquilo C1-4 alquilo C1-4 sustituido con uno o más sustituyentes fluoro cicloalquilo C3-6 y Het1 Het1 es un heteroarilo selecci
