GIOVANNINI, Riccardo,CUI, Yunhai,DOODS, Henri,FERRARA, Marco,JUST, Stefan,KUELZER, Raimund,LINGARD, Iain,MAZZAFERRO, Rocco,RUDOLF, Klaus
申请号：
ES14724085
公开号：
ES2658076T3
申请日:
2014.05.15
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of the formula (I) ** Formula ** wherein A is selected from the group consisting of H and C1-6-alkyl； R1 and R2 are independently selected from the group consisting of H, C1-6-alkyl and C3-6-cycloalkyl, wherein at least one of R1 or R2 is C1-6-alkyl or C3-6-cycloalkyl, wherein the C1-6-alkyl or C3-6-cycloalkyl are optionally substituted with halogens or MeO-, or where R1 and R2 together form a 2- to 5-membered alkylene bridge optionally substituted with halogens, which incorporates 0 to 2 heteroatoms which are independently selected from the group consisting of N, O and S； W is selected from the group consisting of a monocyclic or bicyclic aryl, a monocyclic or bicyclic heteroaryl, a monocyclic or bicyclic heterocyclyl, and a monocyclic or bicyclic cycloalkyl, wherein each of these ring systems is optionally substituted with one or more R3 ； and wherein the heteroaryl comprises up to 4 heteroatoms and one or two rings of 5 or 6 members； R3 is independently selected from the group consisting of C1-6-alkyl, C3-8-cycloalkyl, C1-6-alkyl-O-, benzyl, halogen, HO-, NC-, monocyclic or bicyclic heteroaryl, and monocyclic heterocyclyl of 5 or 6 members containing a heteroatom selected from the group consisting of N, O or S (O) r, wherein the heteroaryl contains up to 4 heteroatoms and one or two rings of 5 or 6 members, and r is 0, 1 or 2, wherein C1-6-alkyl, C3-8-cycloalkyl, C1-6-alkyl-O-, benzyl, heteroaryl and heterocyclyl are optionally substituted with halogens, HO-, acetyl, C1-6-alkyl-O-, oxo, R4-S (O) 2-, R4 being aryl, C3-6-cycloalkyl and / or C1-6-alkyl； And it is selected from the group consisting of a link, -CH2-, -CH2CH2- and -CH2O-； or a salt of any of the above compounds.Un compuesto de la fórmula (I)**Fórmula** en donde A se selecciona del grupo que consiste en H y C1-6-alquilo； R1 y R2 se seleccionan independientemente del grupo que consiste en H, C1-6-alquilo y C3-6-cicloalquilo, en donde al menos uno de R1 o R2 es C1-6-alquilo o C3-6-cicloalquilo,
