CRAWFORD JASON B,GAUTHIER DAVID,BAIRD IANR,WILSON TREVOR R,SKERLJ RENATO,CHEN GANG
申请号：
IN2334/KOLNP/2006
公开号：
IN257630B
申请日:
2006.08.17
申请国别(地区):
IN
年份:
2013
代理人:
摘要：
This invention relates to a process for synthesizing heterocyclic pharmaceutical compound which binds to the CXCR4 chemokine receptor. In one embodiment, the process comprises: a) reacting a 5,6,7,8-tetrahydroquinolinylamine and an alky] alde¬hyde bearing a phthalimide or a di-rertiary-butoxycarbonyl (di-BOC) protecting group to form an imine b) reducing the inline to form a secondary amine c) reacting the secondary amine iwith a haloalkyl substituted heterocyclic compound, to form a phthal-imido-protected or di-tert-butoxycarbonyl protected tertiary amine and d) hydrolyzing the protected amine to obtain a compound having Formula (I).
