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Procedures for selecting anti-CXCR4 antibodies and certain antibodies; nucleic acids for coding antibodies; vectors; Clula HuestPed; production processes; eczema produced by antibodies; compounds; use of selected antibodies I'm here for treatment.
专利权人:
PIERRE FABRE MEDICAMENT
发明人:
KLINGUER-HAMOUR CHRISTINE, GRENIER-CAUSSANEL VERONIQUE.
申请号:
CL2011000730
公开号:
CL2011000730A1
申请日:
2011.04.01
申请国别(地区):
CL
年份:
2012
代理人:
摘要:
The present invention relates to a novel isolated antibody, or the derived compounds or functional fragments of same, capable of binding to CXCR4 but also of inducing conformational changed of the CXCR4 homodimers and/or heterodimers. More particularly, the present invention relates to the 414H5 and 515H7 antibodies, specific to the CXCR4 protein, as well as their use for the treatment of cancer. Pharmaceutical compositions composed of such antibodies and a process for the selection of such antibodies are also covered.PROCEDIMIENTO DE SELECCIÓN DE ANTICUERPOS ANTI-CXCR4 Y ANTICUERPOS SELECCIONADOS; ÁCIDO NUCLEICO QUE CODIFICA LOS ANTICUERPOS; VECTOR; CÉLULA HUÉSPED; PROCEDIMIENTO DE PRODUCCIÓN; HIBRIDOMA QUE PRODUCE LOS ANTICUERPOS; COMPOSICIÓN; USO DE LOS ANTICUERPOS SELECCIONADOS PARA PREPARAR UN MEDICAMENTO PARA TRATAR CÁNCER.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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