Wollastonite (Calcium silicate) has gained attention for its use as a bone graft material. The current invention utilized an agricultural waste (rice straw) to synthesize biocompatible mesoporous wollastonite intended for biomedical applications. Exclusion of TEOS and TMOS in the current process for synthesizing the silicon containing bio-ceramic particles had proven to be economical. Mesoporous wollastonite (m-WS) particles were characterized by transmission electron microscopy (TEM), N2 adsorption-desorption isotherms, and Fourier transform infrared (FT-TR) spectroscopy. The mesoporous wollastonites exhibited high surface area of 353.48 m2/g and were found to be biocompatible with mouse mesenchymal stem cells (C3H10T1/2). Overall, the invention depicted a cheap route for calcium silicate synthesis and extending its use in bone tissue regeneration applications.