FARNABY, William,FIELDHOUSE, Charlotte,HAZEL, Katherine,KERR, Catrina,KINSELLA, Natasha,LIVERMORE, David,MERCHANT, Kevin,MILLER, David
申请号：
ES12753164
公开号：
ES2559631T3
申请日:
2012.08.21
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (I) ** Formula ** in which R 1 represents a hydrogen or fluorine atom or a trifluoromethyl group； R represents a group -X-Y-R3； X and Y each independently represent a bond, an oxygen atom or a group -C (O), -S (O) n, - C (O) NR4, -S (O) 2NR4, -NR4, or -CR4R5 -, provided that X and Y cannot both simultaneously represent a link and provided that if X and Y are both different from a link, then at least one of X and Y represents -CR4R5-； n is 0, 1 or 2； each R 4 independently represents a hydrogen atom or a C1-C6 alkyl or C1-C6 haloalkyl group； each R5 independently represents a hydrogen atom, a C1-C6 alkyl or C1-C6 haloalkyl group or>； = CH-； R3 represents a saturated or unsaturated carbocyclic or heterocyclic ring system of 3 to 10 members, the ring system itself being optionally substituted with at least one substituent selected from halogen, hydroxyl, cyano, oxo, C1-C6 alkyl, C2-C6 alkenyl , C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 alkyl sulfinyl, C1-C6 alkyl sulfonyl, C1-C6 alkylcarbonyl, C1- alkyl C6-carbonyloxy, C1-C6 alkoxycarbonyl, amino (-NH2), -CON (R6) 2, C1-C6-alkyl, di- (C1-C6 alkyl) amino, C3-C6 cycloalkyl, C3-C6 cycloalkyloxy , C3-C6-methyl cycloalkyl, - [O] p- (CH2) qO-R7 and a saturated or unsaturated 4 to 6 membered heterocyclic ring (optionally substituted with at least one substituent selected from C1-C4 alkyl and C1-alkoxy) C4)； each R6 independently represents a hydrogen atom or a C1-C6 alkyl group； p is 0 or 1； q is 1, 2, 3 or 4； and R 7 represents a C1-C6 alkyl group； or a pharmaceutically acceptable salt thereof.Un compuesto de fórmula (I)**Fórmula** en la que R1 representa un átomo de hidrógeno o de flúor o un grupo trifluorometilo； R representa un grupo -X-Y-R3； X e Y representan cada uno independientemente un enlace, un átomo de oxígeno o un grupo -C(O), -S(O)n, - C(O)NR4, -S(O)2NR4, -NR4, o -CR4R5-, a condición de que X e Y no puedan representar ambos simultáneamente
