STRAUB, ALEXANDER,LAMPE, THOMAS,POHLMANN, JENS,RÖHRIG, SUSANNE,PERZBORN, ELISABETH,SCHLEMMER, KARL-HEINZ,PERNERSTORFER, JOSEPH
申请号：
ES04027037
公开号：
ES2457021T3
申请日:
2000.12.11
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compounds of the general formula (I) ** Formula ** in which R 1 represents thiophene (thienyl), which is substituted one or more times with a halogen group moiety； (C1-C8) alkyl and trifluoromethyl, R2 represents one of the following groups: A-, D-M-A-, in which: the "A" moiety represents phenyl； the "D" moiety represents a saturated or partially unsaturated, monocyclic or bicyclic heterocycle of 4 to 9 members, containing up to three heteroatoms and / or chain hetero atoms of the series of S, SO, SO2, N, NO (N-oxide ) me； the remainder "M" represents -CH2-, -SO2- or represents a covalent bond； in which the group "A" defined above, if necessary, may be substituted one or more times with a remainder of the halogen group； trifluoromethyl； oxo； cyano； nitro； carbamoyl； pyridyl； alkanoyl (C1-C6)； hydroxyalkyl (C1-C4) -carbonyl； -COOR27； -CONR28R29； -SO2NR28R29； -OR30； -NR30R31, (C1-C6) alkyl and (C3-C7) cycloalkyl, the (C1-C6) alkyl being able to be substituted, if necessary, with a moiety of the cyano group； -OR27； -NR28R29 and -C (NR27R28)>； = NR29, in which: R27, R28 and R29 are the same or different and independently of each other hydrogen, alkyl (C1-C4), cycloalkyl (C3-C7), alconoyl (C1 -C4), carbamoyl, trifluoromethyl, phenyl or pyridyl, and / or R27 and R28 or R27 and R29, together with the nitrogen atom to which they are attached, form a saturated or partially unsaturated heterocycle of 5 to 7 members with up to three, preferably up to two heteroatoms the same or different from the group of N, O and S, and R30 and R31 are the same or different and mean independently of each other hydrogen, (C1-C4) alkyl, cycloalkyl (C3-C7), hydroxyalkyl (C1- C4) or -COR33, wherein R33 means (C1-C6) alkoxy, (C1-C4) alkoxy (C1-C4) alkyl, (C1-C4) alkoxy-(C1-C4) alkyl, (C1-) aminoalkyl C4), (C1-C4) alkoxycarbonyl, (C1-C4) alkanoyl-C1-C4 alkyl, cycloalkyl (C3-C7), alkenyl (C2-C6), alkyl (C1-C8), which given the case may be substituted with phenyl or acetyl, aryl (C6-C14), hete roar
