Jolanta Grembecka,Tomasz Cierpicki,Sunil Kumar Upadhyay,Shaun R. Stauffer,Rocco D. Gogliotti,Timothy J. Senter
申请号：
US14302219
公开号：
US09212180B2
申请日:
2014.06.11
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates generally to compounds that inhibit the binding of menin and MLL or MLL fusion proteins and methods of use thereof. In particular embodiments, the present invention provides compositions comprising piperidine-containing compounds and methods of use thereof to inhibit the interaction of menin with MLL oncoproteins (e.g., MLL1, MLL2, MLL-fusion oncoproteins), for example, for the treatment of leukemia, solid cancers, diabetes, and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, MLL-PTD and/or menin.
