LE HUEROU, YVAN,BLAKE, JAMES,GUNWARDANA, INDRANI,MOHR, PETER,WALLACE, ELI,WANG, BIN,CHICARELLI, MARK,LYON, MICHAEL
申请号：
ES09747404
公开号：
ES2552643T3
申请日:
2009.05.13
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound selected from Formula I: ** ** Formula and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein: A is selected from a direct bond or CRaRb R1 is selected from hydrogen, halogen, CN, C1-C6 alkyl, C1-C6 alkyl, -O (C1-C6), - S (C1-C6) alkyl, C3-C6 a heterocyclic 4- to 6-membered, phenyl and a 5- or 6-membered, wherein the alkyl, alkenyl, cycloalkyl, heterocyclic, phenyl or heteroaryl are optionally substituted with one or more groups selected from halogen, CN, CF3, C1-C3 alkyl, -O (C1-C3 alkyl), and NRcRd R2 is selected from C1-C6alkyl, -O (C1-C6), -NH (C1-C6), cycloalkyl C3-C6 saturated or partially unsaturated, phenyl, a saturated heterocyclic or partially unsaturated 4 to 6 members, a 5- or 6-membered aryl bicyclic 8 to 10 membered bicyclic heterocyclic 8 to 10 members, and a bicyclic heteroaryl of 8 to 10 members, wherein the alkyl, cycloalkyl, phenyl, heterocyclics, heteroaryls and aryl are optionally substituted with one or more groups selected from OH, CN, halogen, oxo (except not on phenyl, aryl or heteroaryl), CF3, cyclopropyl, cyclopropylmethyl, -SO2Ri, C1-C6 , -O (C1-C6), -S (C1-C6), NReRf, and phenyl, wherein the phenyl is optionally substituted with one or more groups selected from OH, CN, halogen, CF3, C1-C3 alkyl, -O (C1-C3), and NR g R h R3 and R4 are independently selected from hydrogen or C1-C4 alkyl optionally substituted with OH, F, -O (C1-C3) or C3-C6, or R3 and R4 together with the atoms to which they are attached form a 5- or 6-membered R5 is selected from hydrogen and CH3, or A is CRaRb, Ra and Rb are hydrogen, and R3 and R5 together with the atoms to which they are attached form a 5- or 6-membered R6 is selected from hydrogen, F, OH, -OCH3, C1-C3 and cyclopropyl, or A is a direct bond, R6a is hydrogen and R3 and R6 together with the atoms to which they are attached form a ring 5 or 6 membered R6a is selected from hydrogen, F, OH and CH3 R7 is hydrogen, or A is CRaRb, and R3 and R7 together with the atoms to
