LE KhJuROU Ivan (US),ЛЕ ХЮРОУ Иван (US),BLEhJK Dzhejms F. (US),БЛЭЙК Джеймс Ф. (US),GANVORDANA Indrani U. (US),ГАНВОРДАНА Индрани У. (US),MOR Peter Dzh. (US),МОР Петер Дж. (US),UOLLES Ilaj M. (US),УОЛ,LE KHJUROU IVAN,ЛЕ ХЮРОУ Иван,BLEHJK DZHEJMS F.,БЛЭЙК Джеймс Ф.,GANVORDANA INDRANI U.,ГАНВОРДАНА Индрани У.,MOR PETER DZH.,МОР Петер Дж.,UOLLES ILAJ M.,УОЛЛЕС Илай М.,VANG BIN,ВАНГ Бин,CHIKARELLI MARK
申请号：
RU2010150786/04
公开号：
RU0002517194C2
申请日:
2009.05.13
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention concerns novel compounds of formula I: and stereoisomers, tautomers and pharmaceutically acceptable salt thereof, where: A is selected from a single bond or CRaRb； R1 is selected from hydrogen, halogen, CN, C1-C6alkyl, C1-C6alkenyl, -O(C1-C6alkyl), -S(C1-C6alkyl), C3-C6cycloalkyl, 4-6-member heterocycle containing one, two or three heteroatoms selected from a group consisting of oxygen, nitrogen and sulphur, phenyl and a 5- or 6-member heteroaryl containing one, two or three heteroatoms, selected from a group consisting of oxygen, nitrogen and sulphur, where the alkyls, alkenyl, cycloalkyl, heterocycle, phenyl or heteroaryl are optionally substituted with one or more groups selected from halogen, CN, CF3, C1-C3alkyl, -O(C1-C3alkyl) and NRcRd； R2 is selected from C1-C6alkyl, -O(C1-C6alkyl), -NH(C1-C6alkyl), saturated or partially unsaturated C3-C6cycloalkyl, phenyl, saturated or partially unsaturated 4-6-member heterocycle containing one, two or three heteroatoms selected from a group consisting of oxygen, nitrogen an sulphur, 5- or 6-member heteroaryl containing one, two or three heteroatoms selected from a group consisting of oxygen, nitrogen and sulphur, 8-10-member bicyclic aryl, 8-10-member bicyclic heterocycle containing one, two or three heteroatoms selected from a group consisting of oxygen, nitrogen and sulphur, and an 8-10-mbmer bicyclic heteroaryl containing one, two or three heteroatoms selected from a group consisting of oxygen, nitrogen and sulphur, where the alkyls, cycloalkyl, phenyl, heteocycles, heteroaryls and aryl are optionally substituted with one or more groups selected from OH, CN, halogen, oxo (except substitutes in the pheny, aryl or heteroaryl), CF3, cyclopropyl, cyclopropylmethyl, -SO2Ri, C1-C6alkyl, -O(C1-C6alkyl), -S(C1-C6alkyl), NReRf and phenyl, where the phenyl is optionally substituted with one or more groups selected from OH, CN, halogen, CF3, C1-C3alkyl, -O(C1-C3alkyl) and NRgRh； R3 and R4 are
