Bert Vogelstein,Suzanne J. Baker,Eric R. Fearon,Janice M. Nigro
申请号：
DE69032864
公开号：
DE69032864T3
申请日:
1990.02.20
申请国别(地区):
DE
年份:
2013
代理人:
摘要：
Methods and kits are provided for assessing mutations and/or loss of the p53 gene in human tumors. Both deletion mutations and point mutations in p53 are observed in the same human tumor cells and these mutations are clonal within the cells of the tumor. Loss of wild-type p53 genes is responsible for neoplastic progression.
