Oliver AST,Marina BACAC,Sabine BAUER,Sabine IMHOF-JUNG,Christian KLEIN,Stefan KLOSTERMANN,Michael MOLHOJ,Samuel MOSER,Christiane NEUMANN,Joerg Thomas REGULA,Wolfgang SCHAEFER,Pablo UMAÑA,Tina WEINZIER
申请号：
US15764939
公开号：
US20180282410A1
申请日:
2016.09.29
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention generally relates to bispecific antigen binding molecules for activating T cells, more particularly bispecific antigen binding molecules for activating T cells targeting the Robo 4 receptor. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease. In addition, the invention also relates to antibodies that specifically bind to Robo 4.
