Andrew M. Scott,Terrance Grant Johns,George Mark,Anne Murray,Christoph Renner,Gerd Ritter
申请号：
US14226430
公开号：
US20140322130A1
申请日:
2014.03.26
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to EGFR on tumor cells that overexpress EGFR, and on tumor cells that express the truncated version of the EGFR receptor, de2-7 EGF. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.
