FRENVIK, JANNE OLSEN,法兰维克 珍 欧森,法蘭維克 珍 歐森,RYAN, OLAV B.,莱恩 欧拉 B,萊恩 歐拉 B
申请号：
TW106100137
公开号：
TW201726179A
申请日:
2017.01.04
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
The invention provides a method for the purification of227Th from a mixture comprising227Th and223Ra, said method comprising: i) preparing a first solution comprising a mixture of227Th and223Ra ions dissolved in a first aqueous buffer ii) loading said first solution onto a separation material such as a strong cation exchange resin iii) eluting227Th from the separation material, whereby to generate a second solution comprising227Th iv) Optionally rinsing said separation material using a first aqueous washing medium The invention additionally provides a method for forming a radiopharmaceutical comprising complexing the purified227Th, the pharmaceutical product and its use in treatment of disease such as cancer and a kit for generation of such a product.本發明提供一種用於自包含227Th及223Ra之混合物純化227Th的方法,該方法包含: i) 製備包含溶解於第一水性緩衝液中之227Th離子及223Ra離子之混合物的第一溶液; ii) 將該第一溶液裝載至諸如強陽離子交換樹脂之分離材料上; iii) 自該分離材料溶離227Th,由此產生包含227Th之第二溶液; iv) 視情況使用第一水性洗滌介質沖洗該分離材料; 本發明另外提供一種用於形成放射性藥物之包含錯合該經純化227Th的方法、醫藥產品及其在治療諸如癌症之疾病中之用途及一種用於產生此種產品之套組。
