The present invention provides a process for forming a substance with a superstructure and application thereof. The substance with the superstructure comprises vesicle and hydrogel. The vesicle and hydrogel are prepared in a solution with different ionic strength range, respectively.本發明提供一種超結構體的製備方法及其應用,該超結構體包含囊泡和水凝膠。上述之囊泡和水凝膠是在具有不同離子強度的溶液中分別形成。