This invention belongs to pharmaceutical field and relates to a Silybin drug composition packaging having good stability and significant curative effect, and the preparation method thereof. The drug composition packaging of this invention comprises Silybin injection solution and injection solvent separately loaded in the respective container, and packaged together. Before clinical use, the injection solvent and Silybin solution are evenly mixed and diluted in a 5% or 10% Glucose injection solution for performing infusion, so as to simplify the preparation process of Silybin injection and reduce preparation cost, thereby making the large-scale production of Silybin injection simple and feasible.本發明屬醫藥領域,關於一種穩定性好、療效顯著水飛薊賓組成包裝物及其製備方法。本發明上述藥物組成包裝物包括水飛薊賓注射溶液和注射溶媒,兩者分別裝載在各自的容器中,組成包裝在一起。臨床使用前將注射溶媒與水飛薊賓溶液混勻後稀釋於5%葡萄糖或10%葡萄糖注射溶液中進行滴注,這樣簡化了水飛薊賓注射劑的製備過程,降低了製備成本,使得水飛薊賓注射劑的規模化生產簡單可行。