PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for an injection, comprising an amino steroidal muscle relaxant, with the generation of an analog inhibited an injection comprising the same and a method of inhibiting the generation of an analog in the production of a pharmaceutical composition for an injection, comprising an amino steroidal muscle relaxant.SOLUTION: The present invention provides a method for producing a pharmaceutical composition for an injection, comprising an amino steroidal muscle relaxant, the method comprising a step of adding a pH modifier to aqueous solvent in advance, before adding an amino steroidal muscle relaxant to the aqueous solvent.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】類縁物質の生成を抑制したアミノステロイド系筋弛緩薬を含んでなる注射剤用医薬組成物、これを含んでなる注射剤、および、アミノステロイド系筋弛緩薬を含んでなる注射剤用医薬組成物の製造に際しての類縁物質生成を抑制する方法を提供すること。【解決手段】アミノステロイド系筋弛緩薬を含んでなる注射剤用医薬組成物の製造方法であって、アミノステロイド系筋弛緩薬を水性溶媒に添加する前に、pH調整剤を水性溶媒に予め添加しておく工程を含んでなる製造方法。【選択図】なし
