The disclosure specifically provide by before the transplant while and/or be administered to later the II types anti-CD 20 antibodies of individual effective dose come treat need organ transplant such as kidney transplant individual method.In some embodiments, the method can reduce the risk of alloantibody, panel reaction antibody (PRA) and/or graft rejection.In some embodiments, the method further includes applying the dosage of Intravenous immunoglobuin (IVIG) to individual before the transplant.
