您的位置: 首页 > 农业专利 > 详情页

METHODS FOR TREATING PSORIASIS USING IL-17 ANTAGONISTS
专利权人:
НОВАРТИС АГ (CH)
发明人:
ГЮТТНЕР Ахим (CH),МАШАСЕК Маттиас (CH),ПАПАВАССИЛИС Чарис (CH),ЗАНДЕР Оливер (CH)
申请号:
RU2013120957/15
公开号:
RU2013120957A
申请日:
2011.10.07
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of treating psoriasis comprising the following steps: a) administering an anti-IL-17 antibody during an induction regimen, wherein the induction regimen includes a loading regimen, where the loading regimen includes administering five doses of about 150 mg to about 300 mg of an anti-IL-17 antibody each of the five doses being administered weekly starting from week zero; and b) subsequent administration of an anti-IL antibody during a maintenance schedule wherein said anti-IL-17 antibody binds an epitope of an IL-17 homodimer having two chains of the mature IL-17 protein, said epitope comprising Leu74, Tyr85, His86, Met87, Asn88, Val124 , Thr125, Pro126, Ile127, Val128, His129 on one chain and Tyr43, Tyr44, Arg46, Ala79, Asp80 on the other chain, where the anti-IL-17 antibody has K100-200 pM, and where the anti-IL-17 antibody has a half-life in vivo 23-30 days. 2. The method of claim 1, wherein the loading regimen comprises administering five doses of about 150 mg or about 300 mg of an anti-IL-17.3 antibody. The method according to claim 2, where five doses of about 150 mg are administered to the patient if his weight is less than 90 kg, and five doses of about 300 mg are administered to the patient if his weight is greater than or equal to 90 kg. The method of claim 3, wherein the induction regimen further comprises administering to the patient about 150 mg to about 300 mg of an anti-IL-17 antibody for the eighth week. The method of claim 1, wherein the maintenance regimen comprises treating a patient of about 150 mg to about 300 mg of an anti-IL-17 antibody monthly. A method according to any one of claims 1 to 5, wherein the maintenance regimen comprises treating a patient with at least one dose of about 150 mg to about 300 mg of an anti-IL-17 antibody at the onset of relapse. The method of claim 6, wherein the supportive regimen further comprises treating the patient with at least one dose of about 150 mg to about 300 mg of an anti-IL-17 antibody at th
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
相关发明人
相关专利

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充