Harcourt, Dale A.,Gil, Daniel W.,Gomez, Dario G.,Burke, James A.,Heidelbaugh, Todd M.,Wheeler, Larry A.,Garst, Michael E.,Munk, Stephen A.,Chow, Ken
申请号：
AU2012202008
公开号：
AU2012202008A1
申请日:
2012.04.05
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2012202008A120120503.pdf#####CANRPorlbl\DCC\MDT\4231874_ .DOC-5it4/2012 IMIDIAZOLE DERIVATIVES AND THEIR USE AS AGONISTS SELECTIVE AT ALPHA 2B OR 2B/2C ADRENERGIC RECEPTORS Abstract A compound having a structure selected from the group consisting of: in which each x is independently (1) or (2) Y is selected from the group consisting of OSN-(C(R 7)z)swhere each R7 is independently as previously defined fir R1, each z is independently 1-2, and s is 1-3 CH= -CH=CH or YiCH 2 where Yi is 0, N, or S and the dotted lines are optional double bonds, with the pviso that if the ring including Y is a cyclohexane ring or a heterocyclic 5 member ring said ring is not fully unsaturated, and that if Y is 0,N or S, the ring including Y contains at least one said double bond, said compound further having selective agonist activity at the a2B or a2B/a2C adrenergic receptor subtype(s) over the a2A adrenergic receptor subtype, and all pharmacologically acceptable salts, esters, stereoisomers and racemic mixtures thereof.
