A compound of the formula (1) and a process for its preparation. The compounds of the present are used as Therapy in Tissue rejection, leukemias and lymphomas, hipercortisolemia, Stroke, Spinal Cord Injuries, hyperglycemia, thrombocytopenia and Little disease, among other Dolenc Ias.Claim 1: wherein is a compound of formula (1), pharmaceutically acceptable salts, prodrugs, Biologically Active metabolites, isomers and stereoisomers, where the ring is optionally substituted aryl,Carbociclilo C5 - 6 partially saturated or unsaturated or optionally substituted heteroaryl optionally substituted； The Ring C is carbociclilo C5 - 6 partially saturated or unsaturated or optionally substituted heterocycle optionally substituted； Q and T are independently or with the C N, C They are both ondici u00f3n N； The B ring is a Ring of Seven members, where X is - 2, C (R5)- C (R5) -, - C (= o) - (RA), N -, - O -, - S, - S (o) -, or - S (OR) 2 - or when X is - 2 - C (R5), Can form a ciclopropilo Spiro Ring at carbon Atom to which it is attached； and - C (R5) 2C (R5) 2 -, - C (R5) C (R5) 2 -, - C (R5) 2C (R5), OC (R5) - 2 - (RA), N - (2 - (R5) - C (R5) 2N (RA) -, - C (= o) C (R5) 2 -, - C (R5) 2C (= o) -, - or - C (= o) -, - C (= o) - O -,Or - C (R5) 2 - or - or and - C (R5) when Q 2 - or t is n； Z is n or CR4； or the Ring B is a Six membered ring and is where C (R5) 2； Q and T must be n； Z is CR4 or N； or When X is - 2 - C (R5), Can form a Ring ciclopropilo the Spiro carbon Atom which is United； under the condition of X - and or And Z are not links or - or - n, N, N - or C (= o) - C (= o),NC - O - C - o； and under the condition that in X - and a Sulfur Atom is not adjacent to an oxygen Atom or - C (= o)； under the condition of X - and is not - or - C (R5) 2 - or -, - N - C (R5) 2 - or - or - S - C or - 2 - (R5)； r1 is H, F, CL, BR, Coora, ora, alquileno - or - C1 - 3 - aryl optionally optionally replaced their Structures, or alquileno c1-3 optionally substituted heteroaryl - optionally
