Lundstedt, Torbjorn,Seifert, Elisabeth,Lek, Per,Boman, Arne
申请号：
AU2007321460
公开号：
AU2007321460B2
申请日:
2007.11.09
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
There are described compounds of formula (I) in which Rto R are independently selected from hydrogen, halogen, trihaloalkyl, alkyl having 1, 2, 3, 4 or 5 carbon atoms, electron donor groups selected from alkoxy having 1, 2, 3, 4 or 5 carbon atoms, trihaloalkoxy, hydroxy or amino, electron acceptor groups selected from cyano, sulphonic, nitro, or amide； R is an optionally substituted phenyl, benzyl or cyclohexyl group； R is selected from amino, substituted amino or guanidino groups, Z is a saturated or unsaturated C hydrocarbon chain, and salts thereof. A process for their preparation and compositions containing them are also described. The compounds are either agonists or antagonists of a specific adenosine receptor or a number of adenosine receptors and have usefulness for the treatment of inflammation, arthritic conditions, rheumatoid arthritis, osteoarthritis, mental disorders, or for inducing central nerve regeneration.
