ABEL ULRICH,MEYER UDO,ZEMRIBO RONALDS,KRUEGER BJOERN,KUBAS HOLGER
申请号：
ARP110104855
公开号：
AR084516A1
申请日:
2011.12.21
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
This document also deals with the preparation process of these compounds. This compound is a mGluR5 modulator and therefore helps to control and prevent acute and / or chronic neurological disorders 1: a compound selected from formula (1),where: X represents CH2 or C = O； Y represents CR6R7, NR8, O or S； R1 represents H, C1-6 alkyl, or F； R2 represents H, C1-6 alkyl, or F； or R1 and R2 together with the carbon atom to which they are attached form a 3-7 membered ring that can be saturated or unsaturated, where the ring can optionally contain one or two heteroatoms selected from sulfur, oxygen, and nitrogen and where the ring can be optionally substituted with one or more substituents selected from halogen, trifluoromethyl, trifluoromethoxy, C1-6 alkyl, C1-6 alkoxy, amino, hydroxy, cyano, acyl, C1-6alkyl amino, di- (C1-6alkyl ) amino, C1-6alkylcarbonylamino, and oxo；R3 stands for H, C1-6, or F； R4 stands for H, C1-6, or F； or R3 and R4, plus the carbon atoms connected with them, form a 3-7 ring that may be saturated or unsaturated. In this ring, one or two heteroatoms selected from sulfur and oxygen can be selected, (a) Contains one or more alternatives selected from halogen, trifluoroide, trifluoroisoxic, C1-6 tar, alcoxi C1-6, ammonia, hydroxy, cyanogen, ACIO, c1-6amine tar, di - (C1-6 tar) amino, c1-6carboniamino tar and oxo； R5 represents the single ring selected between arilo and the opposite sex,C3-6cycloalkyl, and heterocyclyl； R6 represents H, C1-6 alkyl, or F； R7 represents H, C1-6 alkyl, or F； or R6 and R7 together with the carbon atom to which they are attached form a 3-7 membered ring that can be saturated or unsaturated, where the ring can optionally contain one or two heteroatoms selected from sulfur, oxygen, and nitrogen and where the ring can be optionally substituted with one or more substituents selected from halogen, trifluoromethyl, trifluoromethoxy, C1-6 alkyl, C1-6 alkoxy, amino, hydroxy, cyano, acyl, C1-6alkyl amino, di- (C1-6alkyl ) amino, C1-6
