PROBLEM TO BE SOLVED: To develop internal medicines or food and drink compositions for preventing or ameliorating circadian rhythm modulation and symptoms caused by the same, which contain as active ingredients food ingredients having abundant food experience and no side effects.SOLUTION: Provided are an internal medicine and a food and drink composition for preventing or ameliorating circadian rhythm modulation and symptoms caused by the same, which contain 4'-demethyl nobiletin as an active ingredient. Since 4'-demethyl nobiletin is one of the metabolites of citrus peel component nobiletin which has been ingested as a food ingredient for many years, the internal medicine or the food and drink composition of the present invention has high safety and does not cause any side effects.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2020,JPO&INPIT【課題】 食経験が豊富で副作用の心配のない食品成分を有効成分として含有する、概日リズム変調およびそれに起因する症状を予防又は改善する内服剤または飲食品組成物を開発すること。【解決手段】 ４’－デメチルノビレチンを有効成分として含有する、概日リズム変調およびそれに起因する症状の予防又は改善用の内服剤、および飲食品組成物を提供する。４’－デメチルノビレチンは食品成分として長年摂取されてきたカンキツ果皮成分ノビレチンの代謝産物の一つであるため、本発明の内服剤又は飲食品組成物は安全性が高く副作用の心配がない。【選択図】 図１
