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NITRO-SUBSTITUTED PHENYLPIPERAZINE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICINES.
专利权人:
LABORATORIOS DEL DR. ESTEVE; S.A.
发明人:
ASCHENBRENNER, ANDREA,KRAUS, JUERGEN,TASLER, STEFAN,WUZIK, ANDREAS,QUINTANA-RUIZ, JORDI-RAMON
申请号:
ES05824122
公开号:
ES2375817T3
申请日:
2005.12.29
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
Nitro-substituted phenylpiperazine compound of general formula I, ** Formula ** in which X represents a -NR1R2 moiety or a -OR3 moiety; R1 represents a saturated or unsaturated 3- to 9-membered cycloaliphatic radical, which may be substituted with 1, 2 or 3 substituent (s) independently selected from the group consisting of oxo (= O), thioxo (= S), C1-5 alkyl, -O-C1-5 alkyl, -S-C1-5 alkyl, -C (= O) -OH, -C (= O) -C1-5 alkyl, -C (= O) -O- C1-5 alkyl, -OC (= O) -C1-5 alkyl, F, Cl , Br, I, -CN, -CF3, -OCF3, -SCF3, -OH, -SH, -NH2, -NH (C1-5 alkyl), -N (C1-5 alkyl) 2, -NO2, -CHO , -CF2H, -CFH2, -C (= O) -NH2, -C (= O) -NH (C1-5 alkyl), -C (= O) -N (C1-5 alkyl) 2, -S ( = O) 2-C1-5 alkyl, phenyl -S (= O) 2-, phenyl, phenoxy and benzyl and which may contain 1, 2 or 3 heteroatom (s) selected independently from the group consisting of nitrogen, oxygen and sulfur as a member (s) of the ring and which is linked through a linear or branched group C1-6 alkylene, C2-6 alkenylene or alkynylene C2-6 which may be unsubstituted or substituted with 1, 2 or 3 substituent (s) selected independently from the group consisting of F, Cl, Br, I, -CN, -CF3, -OCF3, -SCF3, -OH, -SH, -NH2, -O-C1-5 alkyl, -S-C1-5 alkyl, - NH- (C1-5 alkyl) and -N (C1-5 alkyl) 2; with the coding that R1 does not represent a tetrahydrofuranyl radical; a heteroaryl radical selected from the group consisting of furyl (furanyl), thienyl (thiophenyl), pyrrolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, imidazolyl, pyrazolyl, oxadiazolyl, thiadiazolyl, triazolyl, pyridinyl, pyridinyl, pyridinyl, pyridinyl pyrimidinyl, pyrazinyl, quinolinyl, isoquinolinyl, benzo [b] furanyl, benzo [b] thiophenyl, benzothiadiazolyl and imidazo [2,1-b] thiazolyl which may be substituted with 1, 2, 3, 4 or 5 substituent (s) selected (s) regardless of the group consisting of C1-5 alkyl, -O-C1-5 alkyl, -S-C1-5 alkyl, - C (= O) -OH, -C (= O) -C1-5 alkyl , -C (= O) -O-C1-5 alkyl, -OC (= O) -C1-5 alkyl, F, Cl, Br, I, -CN, -CF3 , -OCF3, - SCF3
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