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COMPOUNDS OF REPLACED PIRAZOLINE, ITS PREPARATION AND USE AS MEDICINES.
专利权人:
LABORATORIOS DEL DR. ESTEVE S.A.
发明人:
CUBERES ALTISEN, MARIA ROSA
申请号:
ES06762612
公开号:
ES2372307T3
申请日:
2006.07.15
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
Compounds of general formula I: ** Formula ** in which: R 1 represents a phenyl group, which is optionally substituted by one or more substituents selected 5 s independently from the group consisting of methyl, ethyl, F, Cl, Br and CF 3, R2 represents a phenyl group, which is optionally substituted by one or more substituents independently selected from the group consisting of methyl, ethyl, F, Cl, Br and CF3, R3 represents a pyrrolidinyl group, a piperidinyl group or a piperazinyl group, by which each of these groups may be substituted by one or more (C1-C6) alkyl groups, or R3 represents a moiety -NR4R5-, one of the residues R4 and R5 represents a hydrogen atom and the other of these residues R4 and R5 represents an optionally at least mono-substituted pyrrolidinyl group; an optionally at least mono-substituted piperidinyl group; an optionally at least mono-substituted piperazinyl group; an optionally at least mono-substituted triazolyl group; a residue -SO2R6-; a moiety -NR7R8-, or R4 and R5, the same or different, represent a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, a sec-butyl group or a tert-group butyl, R6 represents a (C1-C6) alkyl group; an optionally saturated at least mono-substituted cycloaliphatic group that may be condensed with a mono- or polycyclic ring system; or a phenyl group, which is optionally substituted with one or more (C1-C6) and R7 and R8 alkyl groups, the same or different, represent a hydrogen atom or (C1-C6) alkyl radical, optionally, in the form of an N - corresponding oxide thereof, or one of its salts or one of its corresponding solvates.Compuestos de fórmula general I: **Fórmula** en la que: R1 representa un grupo fenilo, que está opcionalmente sustituido por uno o más sustituyentes seleccionado5 s independientemente del grupo que consiste en metilo, etilo, F, Cl, Br y CF3, R2 representa un grupo fenilo, que está opcionalmente sustituido por uno o más sustituyentes seleccionados independ
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