ROZEMA, DAVID B.,WAKEFIELD, DARREN H.,WOLFF, JON A.,WONG, SO,KLEIN, JASON,LEWIS, DAVID L.,HAGSTROM, JAMES E.,BLOKHIN, ANDREI,TRUBETSKOY, VLADIMIR,HERWEIJER, HANS
申请号：
CA2660842
公开号：
CA2660842C
申请日:
2007.08.17
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti- aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
