ROZEMA, DAVID B.,WAKEFIELD, DARREN H.,WOLFF, JON A.,WONG, SO,KLEIN, JASON,LEWIS, DAVID L.,HAGSTROM, JAMES E.,BLOKHIN, ANDREI,TRUBETSKOY, VLADIMIR,HERWEIJER, HANS
申请号:
EP07841047
公开号:
EP2061443A4
申请日:
2007.08.17
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
The present invention is directed to a class of membrane active polymers useful for cellular delivery of compounds. Conjugation of the described membrane active polymers to targeting, anti-opsonization, and anti-aggregation agents provides polymers suitable for in vivo delivery. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.