David B. ROZEMA,Darren H. WAKEFIELD,David L. LEWIS,Jason KLEIN,So WONG,Jon A. WOLFF,James E. HAGSTROM
申请号：
US13368796
公开号：
US20120230938A1
申请日:
2012.02.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible or labile linkages connecting component parts provides for physiologically responsive activity modulation.
